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What qualities do you need to be a successful scientist? 2018 medicine laureate Tasuku Honjo shares what he believes are the "three c's": curiosity, courage and challenge. #NobelPrize#

How many people has Elon Musk personally murdered via his work helping defund USAID? I've run the numbers. USAID, as people outside of CNN's viewership already know, operates largely as a CIA cutout, placing assets on the ground in countries where the U.S. govt is intervening politically. USAID was instrumental is helping seed the following revolutions/coup d'états/civil wars: Serbia — Bulldozer Revolution (Oct. 2000) Venezuela — coup attempt + sustained OTI funding (April 2002) Georgia — Rose Revolution (Nov. 2003) Ukraine — Orange Revolution (2004) Haiti — Ouster of Aristide (Feb. 2004) Lebanon — Cedar Revolution (2005) Belarus — opposition funding, "Jeans Revolution" and after — attempted, failed (2006) Honduras — Coup against Zelaya (Jun. 2009) Cuba — ZunZuneo / "Cuban Twitter" — attempted, failed (2010–12) Tunisia — "Arab Spring" (2011) Egypt — "Arab Spring" (2011–12) Ukraine — Euromaidan / Revolution of Dignity (2014) Bolivia — anti-Morales funding; 2013 expulsion; 2019 ouster Kyrgyzstan — Tulip Revolution (March 2005) Without U.S. intervention, it's hard to see how any of these would have gotten off the ground. Some back-of-the-envelope math on these conflicts' bodycount: Venezuela (2002): 19 Haiti (2004): ~300 Maidan event (2014): ~100+ killed. Bolivia (2019): 36 Donbas war (2014–2022): 14,200–14,400 military & civilian deaths. Ukraine full-scale war (2022–present), deaths, both sides, mil + civ: roughly 350,000–500,000 killed. So far we're up to somewhere north of 365,000 deaths, more likely north of 500K. What else do we have? USAID also helped fund poppy (heroin) farmers in Afghanistan. Unfortunately I haven't seen estimates of how many have died as a result of this taxpayer funded drug dealing, but I'm assuming they're not small numbers. USAID also worked with groups sexually abusing/trafficking children in Kenya (2021), and the Central African Republic (2013). Much earlier, during Vietnam, USAID helped the CIA arm & feed Hmong guerrillas fighting communist forces (not the worst thing). USAID also helped the Hmong militia & other warlords smuggle opium (a far less forgivable thing). While the final tally is hard to properly calculate, if past is predicate, in helping shutdown USAID, @elonmusk could be saving hundreds of thousands of lives, thousands of African children, & millions of people around the world susceptible to opiate addiction. Get this man a Peace Prize, @NobelPrize

Our Distinguished Scientist John Jumper dropped out of his first PhD, but it led him to AI and biology – and a new doctorate along the way. 🧪 He shares his journey from helping develop #AlphaFold# and being awarded the @NobelPrize to accelerating science with AI – all on our podcast ↓ Timecodes: 00:00 Intro 02:06 The Nobel Prize call 06:35 The "Grand Challenge" breakthrough 09:42 Reactions from the community 12:48 Unexpected use cases 16:04 AlphaFold 3 and diffusion models 26:54 Roman aqueducts 33:46 Designing new proteins 40:40 Does AI think? 46:51 Hannah's outro

Starting 🔜 the @NobelPrize lectures featuring our laureates - CEO @DemisHassabis and Research Director John Jumper - who will discuss their award-winning work on protein prediction and the journey to building #AlphaFold#. Tune in to watch from 9:50am GMT →

At midnight on February 6th, earlier this year, the doorbell to our apartment rang. The doorbell was followed by a pounding on the door. I answered the door and a security person in our building handed me his phone. It was my oldest daughter Eloise. She had found my 26-year-old daughter unconscious on the floor of her apartment and had called 911. The EMT team was already there, but they did not know what was wrong with Lucy or to which hospital they would take her. I threw on some clothes and jumped in an Uber heading east toward Brooklyn. (Lucy lived alone in Williamsburg.) On the way, I learned that they were taking her to Elmhurst, a City trauma hospital in Queens. I arrived about five minutes after the ambulance to join Eloise, Lucy’s mom, and a friend, and waited to learn what was wrong. After about 15 minutes, I asked a nurse where she was. I looked over his shoulder to his computer. Next to her name, it said “non-responsive.” I walked into the emergency room and wandered around looking for her until I found her unconscious on a gurney surrounded by several doctors and nurses. By about 2:30am with the results from a CAT scan, Lucy’s doctors had determined that she had a massive brain hemorrhage and would need an emergency hemicraniectomy to release the pressure on her brain and remove the blood from the hemorrhage. I called our wonderful friend and family doctor Eddie Fisher and explained what was going on. He woke up Josh Bederson, Chairman of Neurosurgery at Mount Sinai, to find out more about Zach Hickman, the neurosurgeon on call that night. Dr. Bederson said Hickman was an excellent surgeon, which was comforting as we had no choice. The surgery to save Lucy’s life began around 3:15am and finished around 5:30am. It was successful. The following day, I joined Lucy in an ambulance while she was being transferred to Mount Sinai on Madison Avenue. Later that day, we determined from Lucy’s Oura ring that her hemorrhage had occurred around 9am, which meant that more than 19 hours had passed from the time of the hemorrhage to the completion of the surgery to release the pressure on her brain (I only wish @ouraring had an alert for this kind of a medical event. Imagine it could call a family member if the wearer doesn’t cancel the alert). I later learned that the standard of care is not to do surgery to save a patient with a large brain bleed if more than five hours have passed since the hemorrhage. Even when the surgery is done, I was told that the likely outcome for the patient is a few months in a nursing home and death from pneumonia. When I met Lucy’s doctors, I did my best to inspire them: “Let’s see what can be accomplished if we give her the best care possible and we invest unlimited resources to restore her to life.” And I promised that whatever we learned we would make available to everyone. Dr. Chris Kellner, her neurosurgeon, and Dr. David Putrino, Director of Rehabilitation Innovation for the Mount Sinai Health System have led Lucy’s care team since that day. Words cannot describe the remarkable and compassionate care that she has received beginning with the EMT team and then from nurses, doctors, therapists, and the army of people who have worked to save her and return her to life. To this day, we have a daily Zoom where we discuss her progress and make adjustments to her care. While her care and oversight have been incredible, the learnings for the Mount Sinai team have also been elucidating and will assist in the care of many others. Lucy began in a bad place. She was in a coma for several weeks and then awoke not being able to breathe on her own, unable to walk, see or speak. Over the last six months, she has recovered her cognition – she understands everything including her circumstance – is able to walk a hundred or more steps at a time with assistance, is making progress with sounds, vowels and consonants and the beginnings of speech, but she remains unable to see. Each day, she makes a little progress, and daily progress compounds. Every day I tell her that she just needs to make a little progress and it won’t be long before she is back. We remain optimistic that Lucy will return to normal function. It will likely take years, but I believe it is only a matter of time, hard work, and technological progress, along with some, and perhaps a lot, of divine intervention. Many people have been praying for Lucy and we are incredibly grateful for the prayers and remarkable support she has received. Lucy’s friends have been with her every day since the beginning, and their presence and friendship have saved her life and helped to rebuild and maintain her spirit. And on a very positive note, Lucy’s challenge has brought together our entire modern family who have all been incredibly devoted to her care and recovery. Lucy's vision and other faculties may require some form of brain computer interface, work that is underway at Neuralink, Precision Neuroscience, Science, Synchron, Nudge, and other companies in the space. If you are going to have a devastating brain injury, now is the best time in history for that to happen. We are living in a world when you can be confident that the blind will soon see again. We are going to do everything we can to help make that happen, including by assisting existing companies in the space. With respect to our promise to make Lucy’s care available to others, we have made good progress. In May, a real estate colleague made me aware of a 93% vacant, brand new, 400,000 square foot Class A+ purpose-built biotech facility on West End Avenue between 65th and 66th Streets that missed the market and was available for sale. The Pershing Square Foundation acquired the building 60 days later. We also put under contract an adjoining 130,000 square foot building at 320 West 66th Street that is currently being used by Saturday Night Live for studio space. The building has 35-foot ceilings with massive column-free spaces that can be converted into superb rehabilitation facilities. We will close on the SNL building in December. We are also acquiring an adjoining vacant lot with additional air rights. With just the existing zoning rights, we can add a 150,000 square feet for a total of 680,000 square feet, a lab footprint larger than Rockefeller University, and that’s without including the potential for an upzoning that would allow for substantially more buildable area on the site’s 3.4 acres with spectacular views of the Hudson. Our goal is to build the world’s greatest brain research, rehabilitation, recovery, human optimization, and longevity institute. We have named it The Ackman Oxman Institute or the AOI for lack of a better name, but also to reinforce the point that Neri and I and our family are all-in on the mission. The AOI will be patient-centric. It will not be an academic research institute that produces lots of papers, a Nobel Prize winner or two, but little if any results for patients. We will be laser-focused on cures, treatments, devices, rehabilitation and exercise equipment, and targeted and basic research with a goal of massively accelerating the time from idea to innovation to production to helping a patient. While the AOI will be a non-profit, it will have highly commercial instincts. The AOI will have its own venture funding and will work to develop innovations to create companies that we will seed, assist, and spinout to ensure technologies, treatments, techniques, and drugs get to patients as promptly as possible. On one 3.4 acre campus in what is still the greatest city in the world, we will do neurosurgery, neuroscience, rehabilitation, nutrition, BCI and device development, human trials, hyperbaric oxygen treatments, and life extension programs, and we will mandate and incentivize collaboration among the teams with no silos, politics, bureaucracy, or any other constraint that is inconsistent with the mission. Mount Sinai will be an important partner and deservedly so, but it won’t be our only hospital or medical school partner as we don’t believe any institution has a monopoly on the best ideas or the best talent. We don’t believe in exclusive relationships because that is not in the best interest of patients. Five years ago, we considered launching a brain institute inspired by Neri’s mom who sadly died from Alzheimer’s. We couldn’t make the math work as the real estate was too expensive and we believed it would be too difficult to recruit the best talent from universities to our effort. Since then, the real estate became available at a 70% discount, universities became a much less attractive place to work due to politics outweighing meritocracy, protests that disrupt learning, the curse of antisemitism, and a decline in funding. Fortunately, during the same time, I made sufficient personal economic progress to make the AOI possible. The advance of AI in the last few years will also enable us to greatly accelerate our mission. AI still has a lot to learn about human intelligence and the brain, and the AOI should be at the forefront of the interplay between the brain and AI. Today, I am making a public filing disclosing a gift from Neri and me of ~$400 million or 10,000,000 shares of Pershing Square Inc. (PS) to the AOI. It is very early days for Pershing Square so these shares are intended to anchor the long-term work of the AOI as the shares compound over time while generating what we expect will be a growing stream of quarterly dividends to fund the Institute. We will also be announcing an additional gift of similar and potentially greater size which won’t be in the form of Pershing Square stock to provide the AOI with the short- and intermediate-term runway necessary to enable it to achieve its goal of becoming a self-sustaining institute, which reinvests all of its revenues, royalties, and the economic rewards of company formation to advance the fields of brain health and human longevity. Neri and I have chosen to anchor the funding of the AOI to maintain vision alignment and limit the need for the organization to focus on fundraising. We expect the AOI to be the best-resourced brain, rehab, recovery, and longevity institute in the world. We are grateful to have been able to form a board which includes Dean Kamen (our generation’s Thomas Edison), George Yancopoulus (CEO of Regeneron), James Rothman (Nobel Laureate), Bernardo Sabatini (neuroscientist), Chris Kellner (neurosurgeon), Olivia Flatto (CEO Pershing Square Foundation), Neri Oxman, and myself. We have recently identified a CEO who we expect to announce by October along with other key hires, and are beginning searches for a Chief Scientific Officer, a Chief AI/Technology Officer, a Chief Operating Officer, a Chief Financial Officer, and other key leadership roles. If you find what we are building compelling and want to be part of the leadership team that creates and builds the AOI from a standing start, please send an email to: search@aoiinst.org with a short note as to why you believe you can help. Please include your best three ideas for the AOI along with a summary of your background and your most important accomplishments. We promise strict confidentiality to those expressing interest in working with us. We have learned from Lucy that the brain can recover from even catastrophic injury. There is so much more work to be done as the mind is a terrible thing to waste. For details from my Pershing Square SEC filing see:

First Principles Ep. 5 with Paul Milgrom One of the most important auction designs in modern history was sold to the FCC on a 3.5-inch disk. Nobel Prize winner Paul Milgrom on auctions, price discovery, and how mechanism design became real-world infrastructure — from spectrum auctions to DeFi. Hosted by @Tim_Roughgarden with @skominers. 00:00 Intro: economics assumptions that are “just wrong” 02:19 Scott Kominers and Tim Roughgarden on the genius of Paul Milgrom 05:35 An intro to the  Glosten-Milgrom model: The paper that created entire fields of economics 07:48 The auction theory breakthroughs of the 1980s 17:15 Why market microstructure matters for DeFi 24:17 When math teaches economics something new 32:38 How theory became spectrum auction design 36:22 The floppy disk that helped convince the FCC 41:05 What changed when auctions moved online 45:28 The auction that reorganized television 1:07:30 What economics and computer science can learn from each other 1:13:22 Futures markets for compute 1:15:12 Paul Milgrom’s advice for builders

First Principles Ep. 4 with Alvin Roth Long before crypto made coordination programmable, Nobel Prize winner Alvin Roth was designing markets where coordination could save lives, matching doctors to hospitals, students to schools, and kidney donors to the patients who need them. Roth explains why markets are not just natural forces, but engineered systems; why the details of timing, congestion, incentives, and trust can make or break a marketplace; and why some of the most important markets are the ones where simply exchanging money can’t do the work. Hosted by @Tim_Roughgarden with @skominers. 00:00 Intro: Why market design matters 04:18 The economist as engineer 08:09 When theory meets the real world 07:02 Fixing the medical residency match 15:32 Why markets unravel 18:22 Redesigning NYC high school admissions 28:05 The hidden problem of congestion 34:47 How kidney exchange saves lives 45:26 How the internet changed market design 48:25 Airbnb, Uber and smarter marketplaces 51:28 Repugnant transactions and moral economics 53:32 When markets need social support 54:32 The unexpected effects of criminalizing surrogacy 01:04:58 Preference signals and the job market 01:18:53 A broken market: resettling refugees and other migrants

There was no award when Newton discovered three laws of forces, nor when da Vinci painted the Mona Lisa. There was no Grammy for Beethoven or Chopin, nor a Nobel Prize in Literature for Homer. Masterpieces do not seek transient trophies but aim to be timeless.

We’re honored that this work was recognized with the 2024 Nobel Prize in Chemistry. 🏅 With AlphaFold 3, we’re expanding beyond proteins to DNA, RNA, ligands and more, and how they interact – bringing us closer to a truly holistic view of biology. Find out more about the breakthrough and its impact 5 years on →

We're developing and using AI to revolutionize scientific discovery - from predicting protein structures with #AlphaFold#, to materials discovery with GNoME. Join our VP Science, @pushmeet, and Professor @fryrsquared as they explore how AI could lead to a new era of breakthroughs that could benefit humanity in countless ways, on Google DeepMind: The Podcast. Watch now ↓ Timestamps: 00:00 Intro 01:13 AlphaFold 06:13 AlphaFold Database 08:14 Weather forecasting 11:24 Creating new materials with deep learning 25:10 Imposter syndrome, being a generalist, and Nobel prize winners 31:21 Choosing the right projects 32:07 Root node problems 34:32 Large language models for science 36:06 Function search and algorithmic discovery 42:10 Math Olympiad 46:26 What’s coming next 48:35 Reflections from Hannah