correction: organic cotton / down for beddings and pillows are great for me
I tried naturepedic organic mattress and they also give me inflammation (and they really drag their feet when you try to return)
avocado mattresses and pillows are no good when I tried in store
best i found is a non organic mattress (beautyrest from mattressfirm) but certain spots of the mattress is more inflammatory than others (maybe corresponding to spring locations and midseam)
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7/ each time I do this I get some kind of systemic inflammation that in particular inflames the brain, which I perceive as lower energy, and can cause memory, learning, executive function impairments
so now I'm much more careful
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turns out I also have a bit of long covid
the covid S1 spike protein was found in my monocytes (a kind of immune cells) along with cytokine signature similar to long covid patients
gonna try maraviroc + statin
# the theory
monocytes are like garbage cans that ingest viral debris and break it down; but for some reason the S1 protein resists breakdown
instead it keeps the monocyte alive for long periods of time (months to years even) and increases its inflammatory signaling
in one mechanism, these monocytes attach to capillary endothelium
-> release inflammatory cytokine
-> microclots form in blood vessel
-> local tissue hypoxia
-> more inflammation
-> attracting more monocytes
-> repeat
this dynamics could partly explain symptoms like fatigue, brain fog, pain, autonomic issues, etc
# treatment
maraviroc (an HIV drug) + statin (a cholesterol drug) blocks the receptors that guide monocytes and bind them to inflamed endothelium -- when the monocytes don't feel the inflammation any more, they kill themselves safely (apoptosis), taking the S1 spike protein with them
so eventually the S1-containing monocytes all die off and inflammation and symptoms mitigated, as the theory goes
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looks like at least part of my food sensitivity goes through the histamine pathways
H1 (loratadine + fexofenadine) and H2 (pepcid) blockers both help lessen my reaction
H1 blockers help with the inflammation I feel when I chew food
H2 blockers help with inflammation in the gut after I swallow
so I likely have a mild version of mast cell activation syndrome
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AlphaProteo designed successful binders for 7️⃣ diverse proteins.
These include two viral ones involved in infection and five involved in cancer, inflammation, and autoimmune disease.
The system generated candidates with strong binding to these targets.
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I tried eight sleep for a few weeks
unfortunately the material is inflammatory for me so I always wake up kinda tired
organic material is much more refreshing
I recovered pretty quickly from the crash actually (i think the extreme anti-inflammatory property of the fast arrested the cytokine storm before it got out of hand), and my HRV last night doubled and was the best this year
I broke the fast this morning starting with blueberries (spitting out the skin tho) then steamed halibut then a ribeye steak (omg it was so good)
I got a bit sleepy after all the eating but feel OK now; much of the fasting benefits still remain but I feel calmer now instead of feeling like I have too much energy to know where to spend them
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generally I find white fish (like sole, branzini, rock fish, etc) to be the safest, least inflammatory source of protein
I also find the fattier the meat, typically more inflammatory it is
white fish < ostrich < salmon < lean beef/lamb < fatty cuts of beef/lamb
quality can matter here because I have had bad experiences from ranch 99's white fish
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