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Mental health doesn’t start in the brain alone. Dr. Ellen Vora explains how the gut, inflammation, and the nervous system all work together. Full episode out now: #TheSecretaryKennedyPodcast#

correction: organic cotton / down for beddings and pillows are great for me I tried naturepedic organic mattress and they also give me inflammation (and they really drag their feet when you try to return) avocado mattresses and pillows are no good when I tried in store best i found is a non organic mattress (beautyrest from mattressfirm) but certain spots of the mattress is more inflammatory than others (maybe corresponding to spring locations and midseam)

7/ each time I do this I get some kind of systemic inflammation that in particular inflames the brain, which I perceive as lower energy, and can cause memory, learning, executive function impairments so now I'm much more careful

turns out I also have a bit of long covid the covid S1 spike protein was found in my monocytes (a kind of immune cells) along with cytokine signature similar to long covid patients gonna try maraviroc + statin # the theory monocytes are like garbage cans that ingest viral debris and break it down; but for some reason the S1 protein resists breakdown instead it keeps the monocyte alive for long periods of time (months to years even) and increases its inflammatory signaling in one mechanism, these monocytes attach to capillary endothelium -> release inflammatory cytokine -> microclots form in blood vessel -> local tissue hypoxia -> more inflammation -> attracting more monocytes -> repeat this dynamics could partly explain symptoms like fatigue, brain fog, pain, autonomic issues, etc # treatment maraviroc (an HIV drug) + statin (a cholesterol drug) blocks the receptors that guide monocytes and bind them to inflamed endothelium -- when the monocytes don't feel the inflammation any more, they kill themselves safely (apoptosis), taking the S1 spike protein with them so eventually the S1-containing monocytes all die off and inflammation and symptoms mitigated, as the theory goes

looks like at least part of my food sensitivity goes through the histamine pathways H1 (loratadine + fexofenadine) and H2 (pepcid) blockers both help lessen my reaction H1 blockers help with the inflammation I feel when I chew food H2 blockers help with inflammation in the gut after I swallow so I likely have a mild version of mast cell activation syndrome

Vigorous exercise, especially high-intensity interval training, is one of the best ways to refresh the body’s energy systems. It works in two ways: mitophagy clears out old, damaged mitochondria, and mitochondrial biogenesis builds new ones. This dual effect boosts cellular energy production, improving both physical and cognitive performance over time. High-intensity interval training is so effective because it creates metabolic stress, which increases lactate levels. That lactate sends a signal to activate PGC-1α, a protein that helps grow more mitochondria. Over time, having more mitochondria makes your muscles better at using oxygen, managing blood sugar, and reducing oxidative stress. The best part? You don’t need long workouts to get these benefits. Even short bursts of intense exercise can improve your metabolism, protect against muscle loss as you age, reduce inflammation, and boost your overall health.

AlphaProteo designed successful binders for 7️⃣ diverse proteins. These include two viral ones involved in infection and five involved in cancer, inflammation, and autoimmune disease. The system generated candidates with strong binding to these targets.

Reflexión El cuerpo registra cada ajuste que hice este mes: respiración, sueño, movimiento, calma, alimentación, presencia. La fisiología cambia con acumulación, no con intensidad. Hoy mi sistema nervioso está más regulado, mi inflamación más controlada y mis ritmos más estables. Este cierre no es final: es una transición hacia un cuerpo más adaptado y consciente. Pensamiento Hoy reconozco cómo se siente mi cuerpo después de un mes de cuidado. Afirmación Mi cuerpo integra cada gesto de salud y se fortalece día a día. #cuerposaludable#

La inflamación afecta la salud mental” Reflexión La inflamación crónica altera neurotransmisores como serotonina y dopamina, afectando ánimo, motivación y claridad mental. No es solo cansancio: es una respuesta inmunológica que impacta el cerebro. Hábitos antiinflamatorios —alimentación real, sueño, movimiento— reducen esta carga y mejoran salud emocional. Pensamiento Hoy elijo un hábito antiinflamatorio que mi cuerpo pueda sostener. Afirmación Reduzco inflamación y mi mente se vuelve más clara y estable. #inflamacion# #saludmental#