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For twenty years, "reversing aging" meant a conference slide and a mouse study, and then on 9 June 2026, a company put a partial-reprogramming therapy into a living person for the first time, so here is the race, ranked by closeness to a dosed human: 1. ER-100 (@lifebiosciences). A virus carries OSK, three of the four Yamanaka factors, into the retina, and eight weeks of doxycycline switch them on, winding a cell's age markers backward without erasing what the cell is. Same factors restored sight in old mouse eyes in 2020, @davidasinclair's lab. Phase 1, 18 people, glaucoma and optic-nerve stroke. Safety only, no efficacy yet. 2. NewLimit (@brian_armstrong). Not yet in anyone. In lab-grown human liver, its candidate pushed old cells toward a younger gene pattern, no damage at high doses. Company-reported. Trial guided 2027. 3. TRN-001 (@turn_bio). Skin, still in a dish. Rolled back human skin cells' aging signature by a decade. Company-reported. Cleared FDA pre-IND, hasn't dosed. 4. SB000 (@ShiftBioscience). Flips one gene instead of all four. A preprint reports it matched or beat the full set on aging clocks, without switching on the pluripotency that makes reprogramming risky. It won't say which gene, which drew doubt. @RetroBio_ is dosing people, but with an autophagy drug, not reprogramming. @altos_labs raised $3 billion and has nobody dosed. Nobody has reversed aging in a person. The fourth Yamanaka factor is a cancer gene. Switch all four on in a mouse and leave them on, and it's dead inside four days, but leave that fourth one out and the same mouse carries the other three for eighteen months with no extra tumours. That gap is why a person was allowed to try this.

Been loving this as background sound lately. The creator blends the Yamanote line's station jingles, announcements, door chimes and train noise into one full audio experience of Tokyo's most-loved loop line. Feels exactly like actually riding it.

Japan's Prime Minister briefed her country with wet hair last night. Beijing would have detained the citizen who filmed it. At 10:29 p.m. on Friday, a magnitude 5.6 earthquake struck Japan's Yamanashi Prefecture, registering a maximum seismic intensity of lower 6 in the town of Fujikawaguchiko at the foot of Mount Fuji. By 11:15 p.m. — forty-six minutes later — Prime Minister Sanae Takaichi was standing at the Prime Minister's Office briefing the nation. Crisis management center activated. Director-general-level emergency gathering team convened. Human life first. Information to the public, promptly and accurately. She was also visibly straight out of the bath. Hair still wet. No makeup. Takaichi posted on her own X account a short time later, in plain language: she had come directly from the bath without time to dry her hair or apply makeup, and apologized for her appearance. She did not have to volunteer that detail. She chose to. That choice is the story. Because somewhere about 1,700 miles to the west, operating under the same physics but a very different political philosophy, the first hour after a magnitude 5.6 earthquake would have looked nothing like this. It would not have been spent activating a crisis center, dispatching emergency teams, and putting the head of government in front of cameras to admit she had rushed straight out of the shower. It would have been spent deciding what to tell the public, what to delete, and which citizen with a camera to detain. We know because we have watched it happen. In Wuhan in early 2020, the doctors who tried to warn the world about a novel coronavirus were summoned by police and forced to sign confessions for "spreading rumors." The citizen journalists who filmed the morgues and the sealed apartment doors — Chen Qiushi, Fang Bin, Li Zehua — were disappeared by the state. Fang Bin would later be sentenced to three years in prison; he was held for the duration. In Zhengzhou in July 2021, passengers drowned trapped in a flooded subway tunnel while state propaganda ran headlines about heroic rescue. When BBC correspondent Robin Brant asked the local government how a metro system less than a decade old could leave passengers to die on a platform, the Henan branch of the Communist Youth League posted his whereabouts to its 1.6 million followers and called for people to track him down. Death threats followed within hours. In Hebei in August 2023, when the floodwaters from Typhoon Doksuri had to go somewhere, authorities diverted them away from Beijing and into Zhuozhou — and the Hebei provincial Party Secretary, Ni Yuefeng, publicly declared the province would "serve as a moat for the capital." Videos of the submerged villages disappeared from Chinese social media within hours. And in Sichuan in 2008, after a magnitude 8.0 earthquake killed at least 5,335 schoolchildren in school buildings that collapsed while government offices nearby remained standing — what citizens named "tofu-dreg schoolhouses" — the writer Tan Zuoren tried to compile a list of the dead. He was sentenced to five years in prison. Huang Qi, the activist who tried to help the parents, got three years; in 2019, the Party gave him twelve more on state-secrets charges. He is still inside. The pattern is not a series of accidents. It is a system. In the People's Republic of China, the function of the state in a disaster is not to serve the public. It is to protect the Party from the public. Compare and contrast. In Tokyo on Friday night, the head of government decided that telling the country what she knew, forty-six minutes after the ground stopped shaking, mattered more than how her hair looked. In Beijing under any equivalent scenario, the head of government would not be at a podium for hours, or days. The citizens with cameras would already be on a list. Wet hair is not the real headline. Wet hair is the headline because of what it accidentally exposes: a democracy is a system that runs toward its citizens in the dark. A dictatorship is a system that hides from them. Sanae Takaichi did not need to apologize for her hair. The Chinese Communist Party owes apologies it will never make, to families whose dead it never named. ACI — Aric Chen | Insights

Tsubaki Factory Member Introduction — Vol.5 💜 Yuumi Kasai — the protagonist the moment she sings ♥ A heroine voice & Yamanashi Ambassador! ▶️ Watch the full video on our Facebook! @tsubakifac_uf #TsubakiFactory# #YuumiKasai# #HelloProject# #Jpop#

𝗗-𝗟𝗜𝗧𝗘 𝗝𝗔𝗣𝗔𝗡 𝗟𝗜𝗩𝗘 𝗧𝗢𝗨𝗥 𝟮𝟬𝟮𝟰 ”𝗗'𝘀 𝗜𝗦 𝗠𝗘” - 𝗘𝗻𝗰𝗼𝗿𝗲 Available only in Japan, exclusively on TELASA (@telasa_jp ) 🔗 [Credit] 🎤 Artist | D-LITE 🎸 Band Bandmaster / Guitar｜Susumu Nishikawa Keyboard｜Hiroshi Uesugi Drums｜Takumi Nishizawa Bass｜FIRE Guitar｜Keisuke Iida Chorus｜Tomohiro ODY Odawara Manipulator｜Takashi Morio 💃 Dancers SARA YAMANAKA / KAHO / MARINA RIO NISHIZUMI / Fumiya / Taabow Kosuke / Shun Suzuki 🎬 Production Production｜Kedama Inc. Director｜Chie Nakamura 🙏 Special Thanks AMUSE Inc. / ON THE LINE Inc. Presented by RND Company Inc. #대성# #DAESUNG# #DLITE# #Ds_IS_ME# #Encore# #Live_tour#

President Xi Jinping noted when holding talks with President Yamandú Orsi of Uruguay @OrsiYamandu @CancilleriaUy that the international situation is volatile and turbulent, and acts of unilateralism and bullying are growing more rampant. China supports Uruguay in assuming the rotating chair of the Group of 77 and China, and stands ready to work with Uruguay to strengthen solidarity and cooperation across the Global South, jointly promote an equal and orderly multipolar world and a universally beneficial and inclusive economic globalization. China attaches high importance to China-LAC relations, supports LAC countries in safeguarding their sovereignty, security and development interests, and supports Uruguay in assuming the rotating chair of both CELAC and MERCOSUR. China stands ready to work with Uruguay and other regional countries to further deepen and substantiate the joint initiative of building a China-LAC community with a shared future.