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Most docking and cofolding methods assume the protein pocket is roughly fixed: place the ligand into a shape that's already there. That assumption breaks on a lot of real targets, and EV-A71 2A protease is a clear example. When a ligand binds, a loop next to the site moves about 4 Å. Every one of the 802 structures in OpenBind's benchmark needs that rearrangement, which is why classical docking into the unbound structure has only 5% success rate. Turns out, the real problem isn't "where does the ligand needs to go" it's "what shape does the protein become when this specific ligand shows up." Ligand and protein are coupled, and you have to solve them together. Pearl predicts that motion from sequence and the ligand alone. On one compound that no other zero-shot method in the benchmark solves, it placed the ligand within 0.28 Å of the crystal structure and got the loop rearrangement right. Modeling induced fit instead of assuming a rigid pocket is a big part of why this holds up on actual programs.

🚀 Unbound Creativity with TRAE SOLO — ハッカソン最新情報 賞金総額が40万円超に! 新たに2社のスポンサー、MiniMax と PixVerse が正式参加しました。そして何より嬉しいお知らせ — コーディングができなくても参加OK。 TRAE SOLO の AI エージェントが技術的な部分を担うので、非エンジニア・ノーコードの方も大歓迎です。 🏆 2つのトラックから選べます 🎥 動画生成(PixVerse 共催) PixVerse で生成した AI 動画を活用し、マーケティング・ゲーミング・映像&エンタメ向けの Web ページやアプリを制作。プロダクトデモ、トレーラー、キャラクター紹介など — 動画がフックとなり、あなたのアプリがそれを形にします。 ⚡ 生産性向上 TRAE をハブに、個人やチームの仕事を本当に効率化するツールやワークフローを開発。開発アシスタント、社内ナレッジ検索、軽量な自動化など。 📌 重要な日程とアクション ▪️Discord に参加: — お知らせ、チームメイト探し、事前ディスカッション用 ▪️プレイベント ワークショップ — 5月27日（水） 21:00〜22:00 (GMT+9): プロダクトチームと一緒に TRAE SOLO & PixVerse を体験。ライブデモやアイデアのヒントも。Discord で開催。 ▪️ガイドブック: 公式参加者ガイドブックは 5月29日まで にメールで配布されます。受信トレイをご確認ください。 ✅ 今すぐやること ▪️まだ登録していない方 今すぐ参加して、優勝を目指しましょう。🏆 ▪️すでに参加済みの方 Luma から共有してお友達を招待しましょう(Luma の URL の末尾にあなたのトラッキングコードが表示されます)。当日に実際に参加した招待者数の 上位5名 に 特別なサプライズ をご用意。🎁 ▪️早めにチーム結成を! 早期にチームを組んだグループには、無料トークンを即時付与 — すぐに開発を始められます。 皆さんと一緒に開発できるのを楽しみにしています — ハッカソンでお会いしましょう! 参加登録はこちらから

Shift Up says the next Stellar Blade game is going well. The company will publish it itself worldwide. The first Stellar Blade was published by Sony. This time, Shift Up will handle everything. That means it will control marketing, global sales, and fan engagement. The company wants full control to do a better job and sell more copies, expect no censorship from Sony Shift Up expects the sequel to perform much better than the first game thanks to its large fan base The original game is still selling well on PC and consoles. In the first three months of 2026, it generated 12.9 billion Korean won, or 27.3% of the company’s total revenue for that period. The company plans to share more details about the Stellar Blade sequel and another game called Project Spirits later in 2026. Shift Up is also building its publishing team. It hired about 60 new developers through a partnership with UNBOUND.

UNBOUND의 최고의 메인 스태프들과 함께. 제가 그동안 즐겨왔던 전설적인 게임을 만드신 분들, 그리고 '미카미 신지'님이 직접 디렉팅하시는 작품을 도울 수 있다는 사실이 큰 영광입니다. 세상을 놀래킬 수 있는 대작은 물론, 빛나는 아이디어의 실험적인 작품까지 준비중이니 많은 기대 부탁 드립니다. #MikamiShinji# #UNBOUND# #SHIFTUP#

It is a profound honor to work alongside the top-tier creative team at Unbound. I am deeply moved to support the visionaries behind the legendary games I’ve cherished my whole life, especially a project directed by Shinji Mikami himself. We are currently preparing a diverse lineup—from massive blockbusters that will shock the world to experimental projects fueled by brilliant, sparkling ideas. Please look forward to what’s coming! #MikamiShinji# #UNBOUND# #SHIFTUP#

アンバウンド(UNBOUND)のメインスタッフの皆様と共に。 私がこれまで愛してきた数々の伝説的なゲームを生み出してきた方々、そして三上真司さんが自らディレクションされる作品にお力添えできることを、心から光栄に思っております。 世界を驚かせるような大作はもちろん、独創的なアイデアが光る実験的な作品まで準備しておりますので、どうぞご期待ください。 #MikamiShinji# #UNBOUND# #SHIFTUP#

「UNBOUND x SHIFT UP」 二つの力が一つとなり、完全新作の開発が始動します。三上真司氏が直接指揮を執るプロジェクトと、SHIFT UPとの融合が生み出すシナジーにぜひご注目ください！ #MikamiShinji# #UNBOUND# #SHIFTUP#

「UNBOUND x SHIFT UP」 Two powerhouses unite to develop a brand-new title. Stay tuned for the incredible synergy between Shinji Mikami's directorship and SHIFT UP! #MikamiShinji# #UNBOUND# #SHIFTUP#

Love and Deepspace | Fallen Crown Through immortality and oblivion, my path leads to your light. 👑Trailer of Xavier's New Event [Fallen Crown] Is Coming! ┈┈▾Giveaway▾┈┈ 💫Follow @Love_Deepspace and Repost for a chance to win $70 (5 winners) before Aug. 7. 👑5-Star Memory Pair from [Fallen Crown] Event From 05:00 on Jul. 25 to 04:59 on Aug. 8 (server time), the limited 5-Star Solar-Slot Memory Pair [Xavier: Nightvow Mooncurse] and [Xavier: Nightvow Requiem] will be available in the Limited Wish Pool. During the event, a maximum of 150 pulls guarantees two event-limited 5-Star Memories and unlocks the Companion [Xavier: King of Darknight]. *See the specific wish rules in the following event preview. 👑Myth: Where Stars Scatter After 05:00 on Jul. 25 (server time), you can read the new Myth of Xavier: Where Stars Scatter in-game. "When their names are spoken once more... Only then will their unfulfilled ambitions, unexpressed love, and unsolved mysteries transform into stories that are passed down for generations. And to endure the test of time can be seen as a divine miracle. 'Eternity' has always been about stories that can immortalize humanity's joys and sorrows." The prophesied Chosen One, summoned by fate... The Mad King, held captive by the crown... The longing to return to Philos draws the threads of their destiny together. When the fated moment arrives amidst the ruins of time—will you still stand by his side? 👑Event: Cycle Unbound Participate in the event to claim 4-Star Solar-Slot Memory Pair [Xavier: Gilded Mirage], [Xavier: Gilded Dreams], [Deepspace Wish: Limited*10], [Diamond*500], and other rewards for FREE! #LoveandDeepspace# #XavierKingofDarknight# #Xavier#

Update: An emergency application has been filed with the court. Several witnesses and I have submitted materials to support the review. The case is not over. Full statement in English below In response to inquiries from multiple German media outlets, I am issuing this statement regarding my interviewee Xu Xiaoren (known online as Macaron), who currently faces imminent deportation from Germany. In March 2025, Xu was the only Chinese citizen I encountered on the Russian frontlines willing to appear on camera, showing his face, to condemn the war: "Every inch of land is paid for in blood. It is inhuman and immoral." For the year that followed, he endured relentless persecution and lived in flight because of this. Guided by professional ethics, I documented his journey through video, audio, and over 100,000 words of investigative notes, cross-verified by multiple witnesses, to record the risks the interviewee faced and to offer him a measure of protection. In thirty years of investigative journalism, this is the first time I have had to do this. It shows how grave I believed the situation to be. In February 2026, Xu escaped Russia. By April, I was informed that he had reached Germany, facing immediate deportation. He asked me to submit these original records to @BAMF_Dialog. I never got the chance. No evidence was reviewed. No contact was made — with me or any other witness. Instead, BAMF ruled his application "manifestly unfounded," dismissing my statement as "mere rumors and unsubstantiated assertions." An emergency application has been filed with the court. Several witnesses and I have submitted materials to support the review. I am grateful for the attention of the press. A man who admitted he entered the war by mistake, who then defected from within it, and what he became over that year, may tell us something about how wars could truly end: the reflection, the suffering, the compassion, the change. It is a battle of the human soul. I ask the German people to hear his story, and to judge for themselves. Full statement in English