与「peripera」相关的搜索结果

peripera 🍑ムードグロイティント  22半熟ピーチ23 いいねピーチ24 完熟ピーチ ぷるんとツヤ感UPなちゅる桃リップ！夏にぴったりどれも発色が良くてお気に入り🥰しかも可愛さ続く耐久リップだから飲食しても色が持続して嬉しい #PR# #peripera# #ムードグロイティント# #メガ割#

水彩画のタトゥー可愛いくて好き🌷 #temporarytattoo# #ETVOS##periperaink##コスメ# #cosmetics# #cosme# #美容# #beauty# #beautynavi##ミネラルクラッシィシャドー#

But here we get to the thing that will confound looking at human and machine as separate units: the possibility of deeper and deeper integration between human and machine. This is the strand of technology that includes: computers being able to work much more symbiotically with us, picking up on all kinds of conscious and sub-conscious signals we release as an interface, brain-computer interfaces, computer-assisted telepathy that helps multiple people better understand each other and work together. The ultimate end is erasing the binary divide between human and machine and opening up any position on that spectrum. On one end, you sitting at a laptop terminal; on the other end, mind uploading, and also everything in between. The hope is that deeply integrated human + machine will outperform separated human + machine, and that this will remain the case all the way up to the technological ceiling. This is the best "far-future AI outcome that I actually like" that I can come up with: * We preserve global political and economic pluralism (no single company or government dominates) all the way up to the technological ceiling. * We humans each get the ability to either take technological upgrades to ourselves, and explore the universe at a level competitive with "pure" machines, or stay as we are, and get some ability to act in the world through having a bot listen to our instructions. * Most of Earth will probably become a highly-regulated nature preserve where anyone can continue living the kind of life they have now (without the pains and annoyances; most challenge will be healthy "good challenge"), and if you want to do more crazy things, you go to space. Make no mistake - this is a ride through a narrow corridor. Things could go off the rails in one of several different ways: AI-on-its-own could get too powerful relative to the alternatives; one country or one company could gain decisive advantage and decide to lock it in permanently, powerful technological ways of destroying each other could cause incalculable harm, or the human + machine integration approach itself ends up preserving not enough of our humanity, and so it ends up being "just another way to make powerful bots". For these reasons, I wish that we can ride through the narrow corridor at 60 kph and not 200 kph, which is why I feel warmly toward "slowdown" / "pause" proposals (including "give us a chance to hit the brakes" ideas like mutually assured compute destruction (as in AI 2040, also previously Dan Hendrycks, and others)). My ideal world is actually one where (i) open weights wins, and (ii) Dean Ball turns out to be completely right that open weights is decelerationist because it deters capex in frontier models [though it will enable more capex in peripherals and applications], because then we get slowdown without any of the downsides of doing it through heavier-handed political means. But also I don't think we should count on the world to naturally give us "convenient" laws of economics and physics. We do have some degree of agency over the laws of politics, plenty of ways to change incentives without putting a king in charge, and we should exercise that.

❓️ PROTEUS Trial - thoughts? A Letter to the Editor & an editorial pubished in EUO ➡️ PROTEUS: A Practice-changing Trial, but Are We Ready to Embrace Perioperative Apalutamide for All High-risk Patients? by Giuseppe Di Lorenzo & Francesco Montorsi @profmontorsi ➡️ PROTEUS Trial the Day After: Practice Changing or Premature Escalation? by Isabel Heidegger...Pierre Blanchard et al @heid58187 ➡️ Thank you to the authors for sharing their valuable insights! @uroweb @mroupret @GPloussard @jteoh_hk @Ric_Campi @CaPsurvivorship @LauraMarandino @RenuEapen @Ecastromarcos @OncoAlert @Sciencedirect

1. Intro Vitalik recently wrote about where the EF should go; Aya added a note to explain how we got here, and why. I’ll write about the execution. We now have enough clarity to stop treating “what is the EF for?” as an open-ended question. Our mandate is clear: The EF exists to ensure Ethereum is, becomes, and remains real permissionless infrastructure for self-sovereignty: censorship (and capture) resistant, free and open source, private, and secure; and capable of supporting sovereignty-preserving coordination at scales where trusted institutions hitherto have been unavoidable. The following are my thoughts on some of the points that follow from the mandate and how we are translating it to action. But first, a short reminder about 2. What the EF is not for We are not here to optimize for EF importance, corpo/pol appeal, or ecosystem popularity. We are also not here to please short-term speculators, prop up TBTF neo-SIFIs, market every app on Ethereum, help anyone look good to their crypto or investor friends, or provide on-demand entertainment for dinner parties and private retreats. 3. What the EF is for: Eliminating weaknesses We are here to defensively strengthen places where Ethereum is, or can still become, extractive, totalizing, or vulnerable to cartel or state capture, or authoritarian tools of surveillance or coercion. We will base our actions on a full examination of what Ethereum is and can be at the protocol layer (what is actually running as “Ethereum”), the access layer (what users use to interact with the protocol), the user layer (the end-users who need and will need Ethereum), and the institutional layer (the intermediated paths that scale self-sovereign usage). The EF exists to harden every surface of Ethereum, including those where Ethereum can remain formally permissionless while becoming practically captured. Some obvious surfaces are the transaction pipeline, staking and network security, access layer standards and interfaces, self-sovereignty norms, privacy expectations, institutional adoption patterns, and social layer governance processes. The primary concerns are similar across most of them: does the status quo and its future trajectory minimize trusted dependencies, minimize points of leverage and capture vectors, make user privacy the default, preserve exit, and make trust assumptions legible? The work starts with the EF itself. We are moving compensation and major financial relationships toward ETH and mandate-compliant Ethereum-native stables, with exceptions where positive law or unavoidable operational constraints require exceptions. Rather than a purity ritual or instruction for people to take unmanaged personal risk, it is robustness, alignment, and product pressure. If the EF’s work is to make Ethereum usable as infrastructure for self-sovereignty, everyone at the EF will increasingly live inside the constraints of the system the EF exists to improve: wallet UX, volatility, accounting, privacy gaps, payment friction, stablecoin trust assumptions, recovery, dependency risk, etc. If we can’t use these tools ourselves, it is unrealistic to expect others to. Ethereum is already mature; those who do not depend on the user-facing stack have no business trying to shape its future, at any layer. The transaction pipeline is next. Preventing toxic MEV capture is core EF work, not a peripheral market-structure concern. Transaction supply, ordering, inclusion, block construction, propagation, and settlement are part of Ethereum’s neutrality boundary. Some MEV may persist as an adversarial phenomenon the protocol contains, but it must be absolutely minimized and, for that to be possible, we must guard against the acquisition of unwarranted influence by its beneficiaries. If credibly neutral execution is subverted by privileged orderflow, cartelized builders, trusted relays, opaque routing, or validators outsourcing into a narrow supply chain, Ethereum will look permissionless while users experience it as intermediated at the moment value moves. EF protocol work will therefore prioritize lower barriers to block building and validation, stronger inclusion guarantees, reduced extraction opacity, competitive transaction pipelines, user-facing legibility of trust assumptions, and more aggressively exploring the open orderflow solution space. None of this is simple. A good solution in one place can aggravate problems elsewhere. FOCIL is good for censorship resistance, but it may introduce more cross-block MEV. While ePBS solves the relayer trust problem, we must make sure that its implementation does not inadvertently obstruct long-term solutions to even larger problems. It would be unacceptable, for example, if ePBS enshrining the builder economy ends up making it harder to reduce reliance on the private orderflow that has emptied out the public mempool. Encrypted mempools may not only reduce pre-execution transparency and pending orderflow visibility, but also shift competitive advantage to new privileged actors, including specialized hardware operators in some designs, while adding protocol complexity. In order to avoid wasting time playing whack-a-mole, we must commit to solving the extraction problem at a whole system scale. Doing so will require creativity, courage, and the understanding that failure to solve this problem is unacceptable. If we fail, we will have left in place an unnecessary barrier to institutional adoption, but, more importantly, we will also have surrendered a core part of the promise of Ethereum - the replacement of extractive middlemen with permissionless, credibly neutral infrastructure and competitive markets. That must not happen. MEV is likely to be the next major front in the cypherpunk war. We must set ourselves up to win here. Privacy is just as fundamental. A public ledger without serious privacy defaults is a surveillance substrate with settlement guarantees. That is not an acceptable end state for the world computer. Unconditional privacy will be readily available across Ethereum, with programmability on top for selective disclosure, proofs, auditability, compliance logic, reputation, governance, identity, and other constraints chosen by users and their communities. The temporal order matters: unconditional privacy must exist first, opt-in constraints come second. It is also important to avoid forcing users to assemble a fragile stack of special wallets, RPCs, bridges, apps, compliance providers, and operational habits to attain privacy. Deep privacy must be more secure than this. Privacy is a condition for Ethereum’s viability as freedom-respecting coordination infrastructure and as such must be robust. Staking must be treated as protocol infrastructure risk. Staking is not merely a yield product, and liquid staking is not merely an app-layer market. If stake, liquidity, validator access, DeFi collateral, and governance influence concentrate around a small set of issuers or operators, Ethereum’s security layer becomes vulnerable to capture through capture of the economic layer around it. EF will support research, specifications, and designs that keep staking permissionless, private where possible, plural in operation, and resistant to intermediaries becoming permanent control points. The access interfaces are where users access either the protocol directly or through intermediated defaults. The primary problem to solve here is not getting Ethereum into more rooms directly, but making its users, both end users and institutions, more self-sovereign and less susceptible to coercion, and avoiding normalization of soft coercion in exchange for reach. EF will not help Ethereum become more acceptable by sanding off the properties that make it uniquely valuable. Ethereum does not need to become another permissioned settlement backend with better branding. It needs to show, in production, that self-sovereign coordination at scale is possible. Across Ethereum, the EF’s defensive work seeks to ensure that Ethereum is infrastructure people can still use when counterparties fail, platforms censor, governments overreach, intermediaries extract, and coordination problems become infeasible for trusted systems to handle. A core part of that is to make that infrastructure secure and robust against capture at every layer wherever capture opportunities can hide. 4. What the EF is also for: Seizing opportunities Shoring up the fundamentals is not enough. Ethereum’s potential is still largely unrealized, but that does not mean that the path ahead is going to be straight. Opportunities must be seized when the time is right. At this moment in time, a number are visible, including: * Ethereum becoming the first quantum-resistant global infrastructure. Ethereum researchers will lead the post-quantum cryptographic migration before the threat becomes urgent, not after it becomes a governance emergency. That means hardening Ethereum’s cryptographic foundations while there is still time to design carefully. The same applies to other long-horizon risks, where waiting for market demand means waiting until the window for principled design has already closed. * Verifiably self-sovereign stack, from soup to nuts, whether local or remote, with no censorship or extraction openings: browsers, wallets, intents, broadcasts, orderflow, inclusion, block construction, proposal, proving, exit, and recovery. Minimal MEV, and zero toxic MEV entrenchment, either in or around the protocol. No execution layer that is formally permissionless but practically gatekept by privileged supply chains. If there’s a funnel towards an extractive private lane, there’s other options that keep the game live. The goal is not only to prevent extraction or capture, but to make credibly neutral execution competitive enough that serious users prefer it. * Making ETH normal digital cash: a private, dignity-respecting, debasement-resistant and surveillance-resistant medium of exchange and store of value, as well as the native asset of private computation and private coordination for both humans and their agents. If Ethereum can make private economic life and private institutional life possible without routing users back through the friction and potential abuse of custodians, surveillance vendors, or permissioned ledgers with softer branding, as well as provide a venue for secure and competitive machine economics, the value unlocks will be immense. * Personal wallets with personal AI agents that users can actually own and run on their own personal computers. Not your keys, not your coins; not your model, not your mind. As agents become interfaces for more economic and social action, the question of who owns the wallet, the model, the memory, the policy, and the signing authority becomes an existential question about sovereignty instead of UX details - we are all users above any other roles, and no one at EF will forget this. * Institutional and enterprise use cases where Ethereum wins by not disappearing into an invisible backend, gatekept by intermediaries or terrible UX, and by not compromising into a compliant fintech rail with web3 branding. Rather, we will win through proving that credibly neutral infrastructure can handle disintermediated coordination so competitively that trusted intermediaries have to meet Ethereum users on Ethereum’s terms. * Security-preserving scaling. L2s and related infrastructure will be able to meet institutional-level needs without accepting dependencies on closed operators, opaque sequencing, custodial UX, or upgrade committees that users cannot realistically exit. Scale is not throughput alone. Scale is the guaranteed availability of self-sovereignty under real load. We are ensuring Ethereum remains the hardest bedrock for settlement, local and worldwide; and beyond that, a civilizational ledger and execution substrate to stand the test of time. When future civilizations speak of the infrastructure they inherited from the Antiquity of the Information Age, their first example should be Ethereum. Ethereum will outlast all of us. More than enough people watching understand this. Many wondered why it needed saying at all, but it did. If you don't believe us or don't get it, we don't have time to try to convince you, sorry. 5. Addressing departures There has been a lot of online speculation about departures from EF, both before and after the mandate. Some people resigned, others were terminated. Some departures were about strategy, some about role fit, some about normal institutional change, and some simply about people deciding that their best work for Ethereum should happen somewhere else. We will not litigate individual personnel matters on Twitter. That is the default because it is better for EF, better for the people involved, and better for Ethereum. People who contributed through EF deserve dignity on the way out. They do not deserve to have their employment history turned into factional content. Where possible, we have let people describe their departures in their own words as a matter of courtesy, and not concession. If public claims materially mislead people about EF’s direction, decision-making, or mandate, we may correct the record at the level of policy, process, and institutional facts. We still will not turn personal files into public spectacle. Ethereum is permissionless. People may disagree, criticize, compete, fork, and build elsewhere. We intend to keep exits dignified and expect others to do the same. It will suffice to say that we are thankful for what all contributors have built; we will continue to do work Ethereum needs. 6. Addressing EF spinouts Some work should and will leave the EF in the months to come. We hope and expect this process to result in some excellent work being done in service of scaling self-sovereign adoption, but we also must take care lest it becomes an abdication of responsibility or an excuse for undisciplined spending. Some work is not mandate-compatible and should not be carried forward with EF funds or EF endorsement, either inside or outside the Foundation. The efforts carried out by the spinouts will vary widely. Some efforts will leave EF because another org would be a better home for them; others will leave because markets should decide on their worth. Some will leave because they are not compatible with the direction set out in the mandate; others because they are useful but not EF work. Just as a spinout is not automatically good because it reduces EF headcount, former EF affiliation is not a claim on EF funding. The question we ask when deciding on funding is not “did this come from the EF?” But, rather the questions that should be asked about all external funding: “Is this work mandate-critical? Would the EF do this work internally if it had the organizational and financial capacity? Is there no better natural home? Can the external party execute without increasing capture risk, private extraction, opacity, or dependence? Does supporting it reduce Ethereum’s dependence on the EF over time, without prematurely transferring resources and legitimacy to new organizations and thereby risking operational failure or mission drift?” EF funding for work being done externally can be appropriate when it is a capacity solution for mandate work - work the EF should responsibly want done; work that protects CROPS; work that advances self-sovereignty and scales it; essential work that no actor can or will reliably do without EF funding; and work that can be scoped, reviewed, and held accountable without creating a permanent dependency. Such funding is not appropriate when it is a lazy continuity payment, a friendship payment, a reputational hedge, a way to avoid making a hard decision, or a way to support work that is not compatible with the mandate. EF has finite funds, finite legitimacy, and a specific mandate. We will spend all three as if they matter. When we say “EF is one of many nodes”, we mean that we intend to be one of many nodes working to keep self-sovereignty and its scaling the North Star, and working to keep CROPS the undisplaceable first-class properties of the network. We don’t mean that we will support orgs or projects with different priorities. Diversity that leads to ecosystem resilience, coordination cost right-sizing, and better decision-making is good. Diversity that leads to mission drift is not. We are not neutral on the direction Ethereum takes. CROPS are not just things we “believe in”, they are characteristics we understand must be thoughtfully prioritized at every fork for Ethereum to realize its potential. We are partisans for and builders of something of such incredible neutrality that it will fundamentally reshape the world we live in; we wish to work with everyone committed to this shared purpose.

Consider the Flash, with the speed and reaction time to pluck bullets out of the air. That wouldn’t keep you from getting shot in the back of the head with a supersonic round with no warning to react to. He could constantly look around, swiveling his head at thousands of RPM to look everywhere, which would be an interesting visual effect, but another option would be to compress a 360 degree visual field into the straight ahead view. There have been novelty “see behind you glasses” forever, but AFAIK, there haven’t been any attempts at giving full 360 degree vision. There have been experiments where psychologists put mirror glasses that flipped the visual field on people to test the adaptability of the brain’s visual system, and it was found that the view change was initially incapacitating, but over the course of a couple weeks, people could adapt to it. Taking them off then took a couple weeks to fully retrain for normal vision. For the Flash, it couldn’t be a camera-and-screen pass-through VR system, because you would need thousands of frames per second to accurately estimate the trajectory of a bullet, but a purely reflective system of curved mirrors could do it.  A non-linear warping would be harder to adapt to than a simple mirroring, because different eye positions would have different distortions. For conventional human reaction speeds, pass-through VR systems with eye tracking could compress everything into the peripheral vision and leave the fovea untouched, which would probably speed adaptation significantly. I can imagine special forces teams having to wear their 360 vision helmets for a couple days prior to a mission, akin to deep sea divers having an extended prebreath and decompression phase. @PalmerLuckey The comic-friendly fix is to just assume that the Speed Force gives the Flash an awareness of anything moving fast in his vicinity, although another thought I had is that while the speed of sound in air is only 330 m/s, the speed of sound in the ground is almost 10x that, so you might be able to “hear a gunshot” with your feet well before you could with your ears.

换个地方继续追剧，《The Peripheral》：西部世界编剧诺兰夫妇打造，2022元宇宙第一神剧，被称为剧场版《头号玩家》的超级科幻神作，看了第一集就觉得还好看看的😂