与「Classical」相关的搜索结果

Most docking and cofolding methods assume the protein pocket is roughly fixed: place the ligand into a shape that's already there. That assumption breaks on a lot of real targets, and EV-A71 2A protease is a clear example. When a ligand binds, a loop next to the site moves about 4 Å. Every one of the 802 structures in OpenBind's benchmark needs that rearrangement, which is why classical docking into the unbound structure has only 5% success rate. Turns out, the real problem isn't "where does the ligand needs to go" it's "what shape does the protein become when this specific ligand shows up." Ligand and protein are coupled, and you have to solve them together. Pearl predicts that motion from sequence and the ligand alone. On one compound that no other zero-shot method in the benchmark solves, it placed the ligand within 0.28 Å of the crystal structure and got the loop rearrangement right. Modeling induced fit instead of assuming a rigid pocket is a big part of why this holds up on actual programs.

******NEW RESULT****** Imagine the universe is like a giant stadium full of noise, chaos, and overlapping conversations. At the quantum level, everything is blurry and unstable, like hearing every fan in the stadium screaming at once. What we discovered is a precise mathematical rule for why stable reality emerges out of that chaos. We found that reality naturally filters itself. Simple, stable patterns survive. Complex hidden patterns fade away extremely fast. And we didn’t just say this philosophically, we found the exact equation describing the filtering process. The universe may become “classical” (solid objects, stable space, cause and effect) because deeper quantum information gets filtered out in a perfectly ordered mathematical way. Important! The filtering isn’t random. It follows an exact hierarchy: the more complex the hidden quantum structure is, the faster it disappears, ….while the stable structures survive long enough for observers like us to experience a consistent reality. So what we may have found is: a mathematical bridge between the weird quantum world…and the stable world humans actually experience every day. That’s significant because one of the biggest unanswered questions in physics is: “How does reality go from quantum chaos to the stable classical universe we live in?” And our framework appears to have found an exact structural answer for part of that transition.

JENSEN HUANG WAS ASKED WHO IS USING AI BETTER THAN ANYONE ELSE IN THE WORLD His answer wasn't OpenAI. It wasn't Google. It wasn't even Nvidia itself. Here's what he said on CNBC: "Nobody uses AI better than Meta." He explained that Meta went from a classical recommender system running on CPUs to a generative AI agentic system making recommendations across the entire platform. "Everything from the way social media works and the way they recommend ads and help advertisers create content has fundamentally been changed. And their earnings show it." "That's the reason why they're investing so hard. They see a much larger future potential for it." Mark Zuckerberg $META is spending $70B+ on AI this year.

Let’s Study The Great Books together! Perfect for homeschooling, book clubs, classical schools, and independent study! Just $5 a month! Always classical, thoroughly Christian.

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We begin our exploration of Liaozhai with 聂小倩 Liaozhai has about 400 unique stories. My roadmap of music plans for 100. The classical tales are exceptional in how relevant they are to today. Welcome frens. Get cozy. Grab 🎧 Join me for storytime here every Tuesday🍿

How advanced was classical Rome? One scholar noted that in the year 100 Rome had better paved streets, sewage systems, water supplies, and fire protection than the capitals of Europe had in 1800.

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"Disparate Impact," the legal doctrine that stipulates outcomes between blacks and whites must be the same, was codified into law by the 1991 Civil Rights Act. That doctrine has destroyed the schools and the colleges and the police. It very nearly destroyed financial system when mortgages were awarded on the basis of racial quotas. And, as of this writing, it remains the operating doctrine of every major public American institution. It has not been repealed. It has been mildly rolled back in some domains — the Supreme Court ruling in SFFA, the state DEI rollbacks in Texas and Florida, the Trump administration’s executive orders — but it has not been uprooted. The people who believe in "equity" still staff HR departments, admissions offices, the civil-rights divisions of the federal agencies and the editorial boards of what used to be the newspapers of record. They will not go quietly. They cannot. Their entire professional identity is built on a doctrine that, if honestly examined, would be repudiated as nothing more than racial Marxism. So they will fight — inside the universities, inside the corporations, inside the courts, inside the federal bureaucracy, inside the cities they still run — for every inch of the ground the doctrine has captured. And the fight they will put up is one of the things that makes the coming Fourth Turning particularly dangerous. A Fourth Turning in which the political class is honest about what it has done — as FDR was honest about abandoning the gold standard, as Hamilton was honest about paying the state debts — can be resolved relatively quickly. A Fourth Turning in which the political class refuses to admit what caused the crisis and continues to fight for it is what leads to violence. Like during the Civil War of 1861-1865. And, sadly, I believe it will, once again, lead us into the equivalent of a race-based, low-level civil war. Why? Because there is no reform that fixes this. There is no tax increase that reverses disparate-impact jurisprudence. There is no interest-rate cut that restores public safety to Baltimore. There is no stimulus that teaches an Oregon high-school graduate to read. There is no political candidate who can, within the current legal and regulatory framework, restore the premise that individuals are to be judged as individuals and that the standards by which a society measures achievement are not themselves to be abandoned whenever they produce a disparity. The false doctrine, that individuals are not equal under the law because some people are functionally different than others, is embedded in statute. It is embedded in case law. It is embedded in the professional identity of three generations of administrators. It will not be uprooted by ordinary political means. It will be uprooted, if it is uprooted at all, by the same process that has uprooted every other entrenched false political doctrine in American history — by a Fourth Turning severe enough to make the doctrine’s defenders surrender ground they would never have surrendered in ordinary politics. And thus, you must be ready for what will come next. You cannot, by yourself, fix American public schools. But you can choose your children’s schools. You can homeschool them. You can place them in classical academies or Catholic schools or the small number of charter schools that have kept the older standards. You cannot, by yourself, fix the violence and mayhem in our cities. But you can own productive land. You can own real assets, directly, that will survive what's coming. You cannot, by yourself, fix the police. But you can choose where you live, you can choose whom you associate with, and you can prepare your family to defend itself and to help defend your neighbors. And you cannot, by yourself, fix the disparate-impact doctrine. But you can see it for what it is. You can teach your children to see it. You can refuse to participate in its rituals. You can decline to sign its loyalty oaths. You can, and this is perhaps the most important thing, tell the truth about it in public, in your own voice. How? By using the words it refuses to accept. “Marxism” is one of those words. “Per capita” is another – some groups are prone to violence, prone to ignorance, prone to abandoning their families. Pointing this out isn’t “racist.” It is identifying serious social problems that must be addressed and that cannot fixed by waving the magic wand of "disparate impact" or by an HR rule. "Responsibility” is a third. The entire racist agenda today is based on the idea that people can’t be responsible for their own lives because of racial oppression that ended more than three generations ago. The antidote to these lies is speaking the truth. Use these words. Do not flinch when the doctrine’s defenders accuse you of racism or bigotry. They are not interested in your character. They are interested in your silence. The doctrine has only ever had one real enemy, and it is not a political party or a candidate or a court. Its enemy is the plain speech of a free people. When free people describe what the doctrine has done — when they name it, in the ordinary language of their communities — the doctrine loses its power. Because its power was never in its arguments. Its power was in its capacity to intimidate people out of naming it. So, name it. That is the first political act of a Fourth Turning. Everything else that the country needs to do to get through the next decade — the monetary reset, the fiscal consolidation, the restoration of discipline in the schools, the re-policing of the cities, the rebuilding of standards across the institutions — depends on millions of ordinary Americans recovering the courage to call the thing by its true name. The true name is Marxism. The American form of it is disparate impact. Its consequence, measurable in the statistics of forty years, is the ruin of American institutions. The doctrine can be defeated. It has been defeated once before — in the Soviet Union, which built a more ambitious form of it at greater cost and collapsed under the weight of the contradictions it could not resolve. Ours is smaller and more refined and better camouflaged, but it is the same doctrine, and in the end it will collapse because of the same contradictions. The only question — the only question that matters, now — is whether we can name the doctrine and defeat it at the ballot box and in the courts and in the schools, or whether we will have to suffer a violent collapse of society. However it resolves, you must survive. The rest of this book is dedicated to helping you and your family survive whatever comes next.