my right foot suddenly flared up with no warning when I woke up today
I can no longer walk any more even though yesterday it was just fine
not the first time, but usually it's my left Achilles heel which has calcific tendonitis
this time it's on the right lateral calcaneal area
luckily I have an iWalk so can still go about my day
what's the cause?
I'm not sure this is directly related to my chronic lyme or long covid but in my (relatively uninformed) mental model all of these symptoms are caused by immune system freaking out at small things and generating cytokine storms -- but do let me know if yall have seen similar conditions
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turns out I also have a bit of long covid
the covid S1 spike protein was found in my monocytes (a kind of immune cells) along with cytokine signature similar to long covid patients
gonna try maraviroc + statin
# the theory
monocytes are like garbage cans that ingest viral debris and break it down; but for some reason the S1 protein resists breakdown
instead it keeps the monocyte alive for long periods of time (months to years even) and increases its inflammatory signaling
in one mechanism, these monocytes attach to capillary endothelium
-> release inflammatory cytokine
-> microclots form in blood vessel
-> local tissue hypoxia
-> more inflammation
-> attracting more monocytes
-> repeat
this dynamics could partly explain symptoms like fatigue, brain fog, pain, autonomic issues, etc
# treatment
maraviroc (an HIV drug) + statin (a cholesterol drug) blocks the receptors that guide monocytes and bind them to inflamed endothelium -- when the monocytes don't feel the inflammation any more, they kill themselves safely (apoptosis), taking the S1 spike protein with them
so eventually the S1-containing monocytes all die off and inflammation and symptoms mitigated, as the theory goes
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