Greg Yang (@TheGregYang) “turns out I also have a bit of long covid the covid S1 spike protein was found i” — TopicDigg

turns out I also have a bit of long covid the covid S1 spike protein was found in my monocytes (a kind of immune cells) along with cytokine signature similar to long covid patients gonna try maraviroc + statin # the theory monocytes are like garbage cans that ingest viral debris and break it down; but for some reason the S1 protein resists breakdown instead it keeps the monocyte alive for long periods of time (months to years even) and increases its inflammatory signaling in one mechanism, these monocytes attach to capillary endothelium -> release inflammatory cytokine -> microclots form in blood vessel -> local tissue hypoxia -> more inflammation -> attracting more monocytes -> repeat this dynamics could partly explain symptoms like fatigue, brain fog, pain, autonomic issues, etc # treatment maraviroc (an HIV drug) + statin (a cholesterol drug) blocks the receptors that guide monocytes and bind them to inflamed endothelium -- when the monocytes don't feel the inflammation any more, they kill themselves safely (apoptosis), taking the S1 spike protein with them so eventually the S1-containing monocytes all die off and inflammation and symptoms mitigated, as the theory goes