The All-In Podcast (@theallinpod)

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”

David Friedberg: It's not rich vs poor, it's makers vs takers. @friedberg: “ The great lie is that there are two sides to society, that is the rich and the poor. And the great truth is that there are two sides that are the makers and the takers. The lie is that the rich are unfairly rich and the poor are unfairly poor, and therefore, the poor must take from the rich. But the truth is that it's the takers that tell you that lie, that the real truth is that artists, plumbers, electricians, woodworkers, computer scientists, people that build, people that make from all walks of life, all income levels, all wealth brackets, are the makers. And the takers are what Sacks calls this intelligentsia, the analysts, the espousers, the armchair mechanics, the critics, the commentators, the politicians. They are the takers. They are the people that watch the rest of society make stuff, build stuff, specifically doing things that create value for other people in society. That's what a maker is.”

POD UP! 🚨 Besties are back to discuss: -- SpaceX's record IPO, Cursor deal, and the first trillionaire -- The modern politburo and the new oligarchy (@friedberg cooks) -- Behind the scenes of the Anthropic Fable ban -- Iran War peace deal (0:00) Bestie intros! (2:41) The New Oligarchs, America's incoming politburo, and learned helplessness (14:18) SpaceX's record breaking IPO, $60B Cursor acquisition, and the trillionaire reactions (33:34) Behind the scenes of the Anthropic Fable ban (1:01:18) Claude psychoanalyzes its creator, Dario Amodei (1:14:31) Iran War MOU and the market impact

Jason Calacanis on SpaceX's Unknown Origin Story: Elon Wanted to Back Up the Biosphere in Space! @Jason: “Most people don't remember this, but when @elonmusk was starting SpaceX, the original idea when he was running around with Adeo and they were looking at some rockets and getting carriage from Russian rockets was to back up the biosphere.” “And he came back from that trip and I remember talking to him about it and he said, ‘I think I just have to make my own rockets because that's actually where the problem is, and it would be easier just to make my own rocket to back up the biosphere.’ And he wanted to put geo-domes, like geodesic domes in space, with all the plants, wildlife, and creatures. What incredible vision. And then there was the necessity of actually getting that up into space, and that's the unknown origin story.”