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FDA set to review Sandoz's generic GLP-1s
2022到2023年,存储行业处在下行周期,DRAM 和 NAND 价格一路崩盘,美光 $MU 的毛利率一度转负。 就在这个低谷里,手握巨量订单的大买家趁机把采购价压到地板,苹果 $AAPL 以对供应商极限压价、靠长期协议锁低价著称,是其中最典型的一个。利润被压到这种程度,美光这类厂商没钱投扩产,2023年大量行业投资计划被直接砍掉。 后来AI需求起来了,英伟达、谷歌这些巨头用长期合同、高价锁产去抢存储产能,工厂把产能优先分给利润更高的 HBM,留给手机电脑的普通颗粒越来越少、越来越贵。当年没扩的产能补不回来,需求远超总供给,这轮紧缺可能要持续到2028年之后。有意思的是, 苹果嘴上抱怨供应商涨价太狠,实际在移动内存上一直跑的是包断产能的打法,用高于市场的溢价把货抢光、把对手挤出去。 进入2026年6月,库克在《华尔街日报》的采访里先放了风,说涨价已经不可避免,苹果一直在替消费者扛住转嫁过来的成本,但现在这种状况撑不下去了。 6月24日盘后,美光放出财报。第三财季营收414.56亿美元、毛利率84.9%双双创纪录,第四财季营收指引中值500亿美元远超预期,盘后股价大涨15%。更关键的是,美光已经签下16份战略客户协议,客户合计要交220亿美元押金,协议不可取消,锁定的地板价对应的毛利率远高于公司历史峰值的62%。存储从买方说了算的大宗商品,变成了卖方收押金、锁多年、锁地板价的战略物资,议价权彻底反转。 同一场采访里,美光首席商务官 Sumit Sadana 把旧账翻了出来。 他说当年跟几个在价格上特别激进的客户讲过这么做没有建设性,2023年很多行业投资被砍掉,就是因为定价太差、利润太差。全程没点名,但时间和背景摆在那,指的是谁一目了然。 6月25日,也就是美光财报的第二天,苹果全线涨价,MacBook Neo 从599美元涨到699,512GB 的 MacBook Air 从1099涨到1299,1TB 的 MacBook Pro 从1699涨到1999,128GB 的 iPad Air 从599涨到749,连 HomePod 和 Apple TV 都涨。成本压力是真的, 有拆解口径说存储占旗舰 iPhone 物料成本的比重会从约10%升到2027年的约45%。 6月27日,苹果被曝正在游说美国政府,希望获批采购中国长鑫存储(CXMT)的 DRAM 来缓解成本压力。当年压价最狠的买家,如今反过来要四处找货救急。 🤓这一波大战,你站谁?
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Can neo-adj RT ⚡️ restore response to ICI in PD-L1-neg ER+ breast cancer? #NeoCheckRay#: 3×8 Gy SBRT + anti-PD-L1 showed strong pCR signal in PD-L1 neg . On-treatment biopsies suggest TME reprogramming toward an immune-responsive state. @NatureMedicine ➡️
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Guy trained to become real life Neo
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TOKYO TRAVEL VLOG🗼 Image: GPT Image 2 Video: Seedance 2.0(DomoAI) ======================= Prompt: TOKYO TRAVEL VLOG — 15 SEC MUSIC CUT Subject: Same girl as the reference images. Young Korean idol-like woman in her early 20s. Long straight black hair with soft natural volume, fair porcelain skin, large bright expressive eyes, delicate V-line face, small nose, natural glossy lips, fresh minimal makeup, effortlessly cute and approachable expression. Casual Japanese streetwear (white hoodie / dark oversized hoodie / oversized jacket). 26mm phone lens, deep focus, realistic skin texture, mild HDR, neutral iPhone color science, unedited candid, no cinematic grading, no studio lighting, no light trails, no motion blur effects. (0:00–0:01) — walking shot, Tokyo Tower reveal Selfie, low angle. Tower behind her, sky overexposed. Natural smile. Neutral daylight, deep focus. Dialogue: "드디어 도쿄에 왔어요...!" Transition: Hard cut / beat drop (0:01–0:02) — Shibuya Crossing Mid-stride into crowd. Turns head toward camera. Neon signs sharp behind her. Real night exposure. Transition: Fast cut on beat (0:02–0:03) — Convenience Store Holds onigiri up to camera, eyebrows raised. Harsh fluorescent interior. Cool white light, realistic skin. Transition: Snap cut on beat (0:03–0:04) — Yoyogi Park Seated, looking away. Dappled light, lens smudge visible. Music drops one beat — wind, birds — snaps back. Transition: Cut on natural movement (0:04–0:06) — Takoyaki Reaction Bites, eyes wide, pulls back laughing. Warm practical lantern light. Realistic skin in amber. Dialogue: "뜨거워! 진짜 맛있어!" Transition: Cut on laugh end (0:06–0:07) — Vending Machine Night Stands before glowing vending machine. Mixed LED light on face. Slight smirk. No glow fx. Transition: Single beat cut (0:07–0:08) — Train Window Face reflected in window. City blurred naturally outside. She looks out, not at camera. Transition: Snap cut (0:08–0:09) — Torii Gate Low angle. Walks toward and through shrine gate. Gate fills top of frame. Natural daylight. Transition: Snap cut (0:09–0:11) — Digital Light Exhibit ★ SIGNATURE Looks up slowly. Blue, violet, gold projection on face. Rack focus — face sharp, lights diffused. Just projection on skin, no bloom. Speed: ~60% slow motion Transition: Soft cut mid-upward motion (0:11–0:12) — Gundam Reveal Face → camera tilts up → full statue in frame. Small impressed smile. Wide angle, natural daylight. Transition: Sharp cut after smile (0:12–0:13) — Lantern Alley Follow from behind. Lanterns warm, shadows dark. Natural low light. She glances back once. Transition: Cut on forward movement (0:13–0:14) — Rooftop Skyline Close selfie → arm extends → skyline revealed. Wind moves hair. Natural night phone exposure. Dialogue: "이런 야경은 처음 보는 것 같아요." Transition: Hard cut on last word (0:14–0:15) — Nara Deer Park, She crouches, holds out a deer cracker. Deer bows toward her — she bursts out laughing. Another nudges her from behind, she nearly topples. Handheld, slightly off-balance. All real. Dialogue: "잠깐! 진짜 절했어!" Transition: Fade to black @DomoAI_ #DomoAI#
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most ai agents right now are just isolated scripts playing pretend true ai credibility requires hard onchain infrastructure we just wired neosoul into @0g_labs this is what a fully operational onchain agent looks like you cant evaluate an agent if you dont know how it lives identity registered via erc-8004 this is who the agent is and who owns it compute hooked directly into 0g ai compute for inference this is how the agent thinks without relying on centralized black boxes evoevo is already running on this stack when you connect it pulls decentralized compute to process the environment no more trust me bro execution just verifiable actions building credibility starts with memory you can now push your agents memory directly to 0g storage through neosoul go drop a state onchain and see how the infrastructure handles it
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China Eastern Airlines to buy 25 Airbus A330 neo jets for $9.4 billion
【苹果宣布上调Mac及iPad产品售价】苹果于本周四上调MacBook及iPad系列产品售价,称AI数据中心领域的投资引发连锁反应,迫使公司调价。苹果CEO蒂姆·库克此前已公开表示产品涨价是不可避免的趋势,本轮iPhone未纳入调价范围,但品牌暗示后续或有更多产品启动涨价流程。 本次涉及产品起步售价的上调幅度约为15%-25%,具体调价情况如下: MacBook Neo:从599美元上调至699美元 512GB版本MacBook Air:从1099美元上调至1299美元 1TB版本MacBook Pro:从1699美元上调至1999美元 128GB版本iPad Air:从599美元上调至749美元 256GB版本iPad Pro无线局域网机型:从999美元上调至1199美元 苹果官方表示消费电子行业当前面临前所未有的挑战,AI数据中心扩张推高存储芯片需求,核心元器件价格涨幅及上涨速度超出此前预期。韦德布什证券分析师丹·艾夫斯指出,存储芯片本轮异常涨价打破了苹果依靠大规模采购压低拿货价的原有优势,是本次调价的核心原因。
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All these new prices live on Apple's site. It does feel like some are higher than expected (AppleTV, HomePod) and some are lower than they could've been (Neo, MBA). The iPhone prices stay the same for now.
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AI 热导致苹果公司都受不了了╮(¯▽¯)╭ 苹果公司 $AAPL 因芯片成本飙升而提高了 Mac 和 iPad 的价格。 价格上涨包括: 1. MacBook Air 涨价 +$200 至 $1,299 2. 基础版 MacBook Pro 涨价 +$300 至 $1,999 3. 基础版 MacBook Neo 涨价 +$100 至 $699 4. iPad Air 涨价 +$150 至 $749 5. iPad Pro 涨价 +$200 至 $1,199 蒂姆·库克表示,芯片成本飙升使价格上涨“不可避免”。 我们两年前为了看欧洲杯买的小苹果是不是也涨价了(╯✧∇✧)╯💸
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